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Biochemical Investigation of cells from these mutants exposed that Lyn is essential in developing ITIM-dependent inhibitory signaling and for activation of certain protein tyrosine phosphatases in just myeloid cells.[thirteen]
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Mice that expressed a hyperactive Lyn allele had been tumor absolutely free and displayed no propensity towards hematological malignancy. These mice have decreased numbers of regular B lymphocytes, down-controlled surface immunoglobulin M and costimulatory molecules, and elevated figures of B1a B cells.
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